CRISPulator: a discrete simulation tool for pooled genetic screens

Abstract Background The rapid adoption of CRISPR technology has enabled biomedical researchers to conduct CRISPR-based genetic screens in a pooled format.The quality of results from such screens is heavily dependent on the selection of optimal screen design parameters, which also affects cost and scalability.However, the cost and effort of implemen

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Exploring the ability of self-report measures to identify risk of high treatment burden in chronic disease patients: a cross-sectional study

Abstract Background Effective self-management of chronic health conditions is key to avoiding disease escalation and poor health outcomes, but self-management abilities vary.Adequate patient capacity, in terms of abilities and resources, is needed to effectively manage the treatment burden associated with chronic health conditions.The ability to me

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The Symbolic Imaginary of Counterculture

The symbolic imaginary of counterculture was fostered by dissent towards the cultural roots of the Western world, by a challenge to traditional norms, values and symbols, and by the rejection of historical identity and national sovereignty.This article aims to discuss some of the aftermaths of the counterculture Detox of the 1960s as resulting from

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